1q: an alfa helix of a protein is most likely to be disrupted if a missense mutation introduces the following aminoacid with in the alpha helical structure ?
b. aspartic acid
explanation : alfa helix of a protein can be disrupted due to the introduction of the following aminoacids :
1. proline : the imino group of proline is not geometrically compatible with the right handed spiral of the alpha-helix
2. charged aminoacids : glutamate ,aspartate, lysine, arginine and histidine .
3. aminoacids with bulky side chains : tryptophan
4. aminoacids that branch at the beta-carbon : valine and isoleucine .