18 - biochemistry mcqs - 154 to 155

154) True about Heparin is

a. Basic in nature

b. Contains Glucronic Acid

c. LMW Heparin selectively inhibit Xa

d. no effect on platelet

Answer : c) LMW Heparin selectively inhibit Xa

Reference: Chaterjee 6^th Edition Page 39

155) About PGE₂

a. Synthesized in fetus

b. Closes the ductus arteriosus

c. Both

d. None

Answer : b) Closes the ductus arteriosus

Reference: Tripathi 5^th Edition Page 159

17 - biochemistry mcqs - 143 to 153

143) Urea synthesized mainly in

a. Liver

b. Heart

c. Kidney

d. brain

Answer : Liver

Reference: Chaterjee 6^th Edition Page 411

144) The End product of purine metabolism is

a. Urea

b. Creatinine

c. Uric Acid

d. GLycine

Answer : c) Uric Acid

Reference: Chaterjee 6^th Edition Page 212

145) Folic acid antagonist for Cancer is

a. Methotrxate

b. Vincristine

c. Cyclosporine

d. Azathioprine

Answer : a) Methotraxate

Reference: Tripathi 5^th Edition Page 772

146) In Galactosemia the Cataract is due to the production of

a. Sorbital

b. Galactose

c. Glucose

d. Galactositol

Answer : d) Galactositol

Reference: Chaterjee 6^th Edition Page 312

147) Following are causes of Vitamin B 12 deficiency except

a. Strict vegetarian

b. Blind loop Syndrome

c. Diphyllobothrium latum infection

d. Chronic Blood loss

Answer :D) Chronic Blood Loss

Reference: Chaterjee 6^th Edition Page 182

148) Hyaluronic acid is made up of

a. N-Acetyl Glusosamine

b. D- GLucuronic Acid

c. Both

d. None

Answer : C) Both

Reference: Chaterjee 6^th Edition Page 38

149) Fluoride inhibits

a. enolase

b. Glukokinase

c. Aldolase

d. Phosphofructokinase

Answer : a) Enolase

Reference: harper 24^th Edition Page 178

150) Thiamine rich in

a. Unpolished rice

b. Fish

c. Soyabean

d. All of these

Answer : a) Unpolished rice

Reference: Chaterjee 6^th Edition Page 159

151) The initial change seen in Hyperventilation regarding PCO₂ is

a. No changes

b. Increased PCO₂ with increased pH

c. Normal PCO₂ with increased pH

d. Decreased PCO₂ with increased pH

Answer : d) Decreased PCO2 with increased pH

Reference: Chaterjee 6^th Edition Page

152) Characteristics of Insulin resistant syndrome all except

a. Hypoglycemia

b. May be associated with PCOD

c. Obesity

d. Hyperglycemia

Answer : Hypoglycemia

Reference: Harrison 15^th Edition Chapter 77

153) FSH and LH are Produced by

a. Anterior pituitary

b. Hypothalamus

c. Placenta

d. Ovary

Answer : A) Anterior Pituitary

Reference: Ganong 22^nd Edition Page 397

16 - biochemistry mcqs - 132 to 142

132) Vitamin useful in the treatment of Hartnup’s disease is

a. Biotin

b. Niacin

c. Folic Acid

d. Thiamine

Answer : b) Niacin

Reference: Harrison 15^th Edition Chapter 353

133) Ketogenic amino acid

a. Leucine

b. Valine

c. Alanine

d. Tryptophan

Answer : Leucine

Reference: harper 24^th Edition Page 310

134) Maple Syrup Urine Disease is due to defect in the metabolism of

a. Unbranched aminoacid

b. Phenyl alanine

c. Branched Chain Amino Acid

d. Tyrosine

Answer : c) Branched Chain Amino Acid

Reference: Chaterjee 6^th Edition Page 456

135) Why muscle glycogen is not useful in elevation of Glucose level of blood because muscle does not contain

a. Glucose – 6 – phosphatase

b. Phosphorylase

c. Cyclic AMP

d. Protein Kinase

Answer : a) Glucose – 6 – phosphatase

Reference: Chaterjee 6^th Edition Page 291

136) Irreversible enzyme step all except –

a. phosphofructokinase

b. Phosphohexose isomerase

c. hexokinase

d. Pyruvate kinase

Answer : B) Phosphohexose isomerase

Reference: Chaterjee 6^th Edition Page 306

137) NADPH not produced for fatty acid synthesis from

a. HMP shunt

b. malic enzyme

c. lactic dehydrogenase

d. isocitrate dehydrogenase

Answer : c) lactic dehydrogenase

Reference: Chaterjee 6^th Edition Page 355

138) The main role of Vitamin K is

a. Carboxylation

b. Formatiuon of active succinate

c. Heme systhessis

d. Synthesis of Fatty acid

Answer : a) Carboxylation

Reference: Chaterjee 6^th Edition Page 155

139) Enterohepatic circulation of bile salt is affected and that leads to

a. Vitamin K deficiency

b. Hypertension

c. Hemolytic anemia

d. Diabetes Insipidus

Answer : a) Hemolytic Anemia

Reference: Chaterjee 6^th Edition Page 155

140) Bile salts is produced from

a. Cholesterol

b. Amino acids

c. Glycogen

d. Lecithin

Answer : a) Cholesterol

Reference: Ganong 22^nd Edition Page 501

141) Vitamin K deficiency occurs in

a. Obstructive Jaundice

b. Hemolytic Jaundice

c. Prehepatic Jaundice

d. Secondaries liver

Answer : a) Obstructive Jaundice

Reference: Chaterjee 6^th Edition Page 155

142) Antiracchitic Vitamin D is activated in the following organ

a. Muscle

b. Lungs

c. Kidney

d. Intestine

Answer : c) Kidney

Reference: Ganong 22^nd Edition Page 388

15 - biochemistry mcqs - 121 to 131

121) Stop Codons

a. UAG

b. UGA

c. UAA

d. All

Answer (d) All of the above

Reference: Harper 27^th Edition Page 366

122) Weakest bond

a. Vanderwalls bond

b. Covalent

c. Ionic

d. Gravitational

Answer (a) Vanderwalls bond

Reference: Harper 27^th Edition Page 7

123) All of the following are involved in various steps of Electron transport chain except:

a. NADP

b. NAD

c. Co Enzyme Q

d. CoA

Answer (a) NADP

Reference: Harper 27^th Edition Page 103

124) Consumption of Ethanol leads to increased levels of

a. Lactate

b. acetaldehye

c. NADH

d. All of the above

Answer: All of the above

Reference: Harper 27^th Edition Page 225

125) Un acceptable type of Missence Mutation is

a. Hb M

b. Hb Hikari

c. Hb S

d. None

Answer : (A) Hb M

Reference: Vasudevan 2^nd Edition Page 308

New Hb	Effect
Hb Bristol	No functional Change
Hb Sydney	No functional Change
Hb Hikari	Acceptable Mistake
Hb S	Partially Acceptable Mistake
Hb M	Unacceptable Mutations
Hb Tak	Nonsense Mutations
Hb Constant Spring	Production of “Run on Polypeptide”

126) Pentose Sugar in Nueclic acid

a. Ribose

b. Deoxyribose

c. Both

d. None

Answer (C ) Both

Reference: Chaterjee 6^th Edition Page 27 and Harper 27^th Edition Page 298

127) Vibration Property of Molecules is checked by

a. Infra red Spectroscopy

b. Electron Microscopy

c. Light Microscopy

d. None of the above

Answer: a) Infra red Spectroscopy

Reference: See Wikipedia, Infrared spectroscopy, http://en.wikipedia.org/wiki/Infrared_spectroscopy (optional description here) (as of Nov. 6, 2006, 21:27 GMT).

Infrared spectroscopy works because chemical bonds have specific frequencies at which they vibrate corresponding to energy levels. The resonant frequencies or vibrational frequencies are determined by the shape of the molecular potential energy surfaces, the masses of the atoms and, eventually by the associated vibronic coupling. In order for a vibrational mode in a molecule to be IR active, it must be associated with changes in the permanent dipole. In particular, in the Born-Oppenheimer and harmonic approximations, i.e. when the molecular Hamiltonian corresponding to the electronic ground state can be approximated by a harmonic oscillator in the neighborhood of the equilibrium molecular geometry, the resonant frequencies are determined by the normal modes corresponding to the molecular electronic ground state potential energy surface. Nevertheless, the resonant frequencies can be in a first approach related to the strength of the bond, and the mass of the atoms at either end of it. Thus, the frequency of the vibrations can be associated with a particular bond type.

Simple diatomic molecules have only one bond, which may stretch. More complex molecules may have many bonds, and vibrations can be conjugated, leading to infrared absorptions at characteristic frequencies that may be related to chemical groups. The atoms in a CH₂ group, commonly found in organic compounds can vibrate in six different ways, symmetrical and asymmetrical stretching, scissoring, rocking, wagging and twisting.

In order to measure a sample, a beam of infrared light is passed through the sample, and the amount of energy absorbed at each wavelength is recorded. This may be done by scanning through the spectrum with a monochromatic beam, which changes in wavelength over time, or by using a Fourier transform instrument to measure all wavelengths at once. From this, a transmittance or absorbance spectrum may be plotted, which shows at which wavelengths the sample absorbs the IR, and allows an interpretation of which bonds are present. This technique works almost exclusively on covalent bonds, and as such is of most use in organic chemistry. Clear spectra are obtained from samples with few IR active bonds and high levels of purity. More complex molecular structures lead to more absorption bands and more complex spectra. The technique has been used for the characterization of very complex mixtures however.

128) The investigation for Thiamine deficiency is

a. RBC Transketalose

b. Blood Sugar

c. Serum Creatinine

d. All of the above

Answer : A) RBC Transketolase

Reference: Harper 27^th Edition Page 497

129) Casals Necklace Pattern is seen in

a. Thiamine Deficiency

b. Riboflavin Deficiency

c. Niacin Deficiency

d. All of the above

Answer C) Niacin Deficiency

Reference: Achar 3^rd Edition Page 89

130) All are examples of detoxication reactions except

a. Oxidation

b. Reduction

c. Hydrolysis

d. None of the above

Answer (d)None of the above

Reference: Chaterjee 6^th Edition Page 483

131) Vitamins needed for the synthesis of Co Enzyme A

a. Pyridoxine

b. Pantothenic Acid

c. Both

d. None

Answer C) Both

Reference: Chaterjee 6^th Edition Page 167

14 - biochemistry mcqs - 108 to 120

108) If the pH is 7.4 then the Hydrogen Ion concentration is

a. 40 mmol/ml

b. 7.4

c. 50

d. None of the above

Answer (a) 40 mmol/ml

Reference: Harper 27^th Edition Page 9

Ä When pH is 7.4, the H+ ion concentration is 40 nanomoles/L

109) Anion gap

a. Is the difference between the unmeasured anion and cation

b. Is the difference Measured cations and Anion

c. Both

d. None

Answer (c) Both of the above

Reference: Chaterjee 6^th Edition Page 630

110) Trypsin is a

a. Serine Protease

b. Maltase

c. Lipase

d. None of the above

Answer : a) Serine Protease

Reference: Chaterjee 6^th Edition Page 397

111) Scurvy is due to deficiency of

a. Vitamin A

b. Vitamin C

c. Vitamin B₁

d. Vitamin B₂

Answer (b) Vitamin C

Reference: Chaterjee 6^th Edition Page 158

112) All of the following components are the common substance with Anti Oxidant properties Except

a. Vitamin D

b. Vitamin C

c. Vitamin E

d. Selenium

Answer a) Vitamin D

Reference: Chaterjee 6^th Edition Page 128, 129

113) In India the major source of Vitamin D is

a. Sunlight

b. Injections

c. Diet

d. None of the above

Answer (a) Sunlight

Reference: KD Tripathi 5^th Edition Page 303

114) A person on a fat free carbohydrate rich diet continues to grow obese. Which of the following lipoproteins is likely to be elevated in his blood?

a. Chylomicrons.

b. VLDL.

c. LDL.

d. HDL.

Answer: 2. VLDL.

Reference : Harper 25th Edition Page 296, Harrison 15th Edition Page 2250

115) Enzyme defcint in Alkaptanuria is

a. Homogentiase Oxidase Deficiency

b. Folate Synthetase

c. DNA Gyrase

d. Transpeptidases

Answer (a) Homogentiase Oxidase Deficiency

Reference: Harper 27^th Edition Page 259

116) The enzyme deficient in Criggler - Najjar Syn Type I is

a. Folate Synthetase

b. DNA Gyrase

c. Transpeptidases

d. Udp Glucornyl Transferase

Answer: (d) Udp Glucornyl Transferase

Reference: Harper 27^th Edition Page 270

117) Which of the following is not a HomopolySaccaride

a. Heparin

b. Dextran

c. Inulin

d. Starch

Answer Heparin

Reference: Chaterjee 6^th Edition Page 35

118) Fatty acid synthesis complex does not contain this enzyme used in fatty acid synthesis

a. Acetyl coa carboxylase

b. Enoyl reductase

c. Ketoacyl reductase

d. Hydratase

Answer (a) Acetyl coa carboxylase

Reference: Harper 27^th Edition Page 197

119) Metabalic alkalosis occurs in

a. Recurrent vomiting

b. Diabetic Ketosis

c. Diarrhoea

d. All of the above

Answer (a) Recurrent Vomiting

Reference: Harrison 16^th Edition Page 268

120) Major anion in ECF

a. Protein

b. Cl-

c. HCO3

d. None of the above

Answer (B) Cl^-

Reference: Ganong 22^nd Edition Figure 1.27